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I have the braff + so these meds were recommended to kill the rest of the bad guys after 13 months of Ipi/nivo immunotherapy and surgery to remove all the axillary lymph node under my left arm.

November 11, 2025
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A MyMelanomaTeam Member

I take both of these meds and have for 3 years now. I have been very successful with them. I did/ do suffer several side effects. Nausea was the worst and lasted the longest. Eye’s blurry sometimes but optometrist said I have 20/20 vision. I have joint pain which is a real pain but, I have some mild pain med to take in case nothing else helps. I have chemo brain which sure messes with my ability to think or remember like I once did. Overall, I can’t complain. Over the past few months the nausea has stopped but the blurred vision, memory and energy are still an issue. I refuse to give in to those as long as possible. I do hope you are spending time outside and able to get some walks in. That is my part in fighting this beast. I have too much to do and see to slow down. I even bought a golf cart to ride around on with my dogs on leashes running beside me like I am Santa and they are my reindeer ! May look crazy but heck I don’t care. Having as much fun as possible every chance I get!! Thinking about you!!

March 13
A MyMelanomaTeam Member

Guy, it turns out my oncologist feels differently about the new meds I'm on and has discontinued them:)). These are more to protect against any new growth not to kill further bad guys as I understood previously. Guess I didn't have my "listening" ears on that day:).

November 12, 2025
A MyMelanomaTeam Member

David,

My 12 months of of Ipi/nivo treatment apparently eventually knocked out my three left lung tumors. And possibly kept anything recurring after my left brain tumor excision surgery.

I certainly wish you all the best.

Guy

November 12, 2025
MyMelanomaTeam

What side effects are you experiencing with Braftovi (encorafenib) and Mektovi?

It sounds like you're going through a tough time with targeted therapy after immunotherapy and surgery. BRAF inhibitors like Braftovi can cause several side effects that might be contributing to how you're feeling.

Common side effects from Show Full Answer

What side effects are you experiencing with Braftovi (encorafenib) and Mektovi?

It sounds like you're going through a tough time with targeted therapy after immunotherapy and surgery. BRAF inhibitors like Braftovi can cause several side effects that might be contributing to how you're feeling.

Common side effects from BRAF and MEK inhibitor combinations include:

* Headaches
* Fatigue and weakness
* Skin issues (rashes, sensitivity to sunlight, peeling or cracking on hands and feet)
* Nausea and gastrointestinal problems
* Joint and muscle pain
* Hair loss or thinning (typically occurring 3-15 weeks into treatment)

The specific side effects you experience can vary from person to person, even with the same medications. Some people find that certain symptoms improve as their body adjusts to treatment, while others may need help managing ongoing issues.

It's really important to talk with your cancer care team about what you're experiencing. They can help manage your side effects and may be able to adjust dosages or provide supportive medications to help you feel better while still getting the cancer-fighting benefits of your treatment.

November 11, 2025

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