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Real members of MyMelanomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Did anyone use or is using chemotherapy for melanoma? Braf negative

A MyMelanomaTeam Member asked a question 💭
Croatia
April 8
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A MyMelanomaTeam Member

Hi Marta. Sorry to hear immunotherapy didn’t work for your mother. You could ask her doctor about participating in a clinical trial for RP1. It’s a new drug that has shown promising results for melanoma patients who fail immunotherapy. Phase 3 trials are currently available in the US and Europe. Based on positive results, it is currently under review in the US pending approval to provide a treatment option for melanoma patients who fail immunotherapy. Here is a link to the clinical trial with available locations shown at the bottom:

https://clinicaltrials.gov/study/NCT06264180

ClinicalTrials.gov
https://clinicaltrials.gov/study/NCT06264180
April 9
A MyMelanomaTeam Member

My mother was taking immunotherapy Nivolumab and it did not work, she will go for chemo now because she has some another problems and she cant take any other medication of immuno. Sorry for bad english. We know that chemo is not very good option for melanoma but we hope

April 8
A MyMelanomaTeam Member

Hi Marta.... my wife Martha has melanoma on her scalp... she went thru a skin graft surgery last fall.... and now is taking immunotherapy sessions

April 8
MyMelanomaTeam

Has anyone used or is using chemotherapy for BRAF-negative melanoma?

Chemotherapy isn't commonly used as a first-line treatment for melanoma anymore. It's typically reserved for situations where other treatments haven't worked or when melanoma has spread extensively.

For BRAF-negative melanoma, immunotherapy is usually Show Full Answer

Has anyone used or is using chemotherapy for BRAF-negative melanoma?

Chemotherapy isn't commonly used as a first-line treatment for melanoma anymore. It's typically reserved for situations where other treatments haven't worked or when melanoma has spread extensively.

For BRAF-negative melanoma, immunotherapy is usually the preferred treatment approach. This includes medications like pembrolizumab (Keytruda), nivolumab (Opdivo), and ipilimumab (Yervoy), which help activate your immune system to fight the cancer.

Chemotherapy may be considered for metastatic melanoma after trying other treatment options first. It can help shrink tumors in some people, though it doesn't work for everyone.

If you have uveal melanoma that's spread to the liver, there's a newer option called Hepzato Kit (approved in 2023) that delivers chemotherapy directly to the liver.

Since you're BRAF-negative, you wouldn't be a candidate for BRAF/MEK inhibitor combinations, but immunotherapy has shown strong results for many people. It's worth discussing all available options with your oncologist to find the best treatment plan for your specific situation.

April 8

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