Hi Patricia. The fatigue is a very common symptom and one I fight daily. Most days I try to take a nap after lunch. I also have adrenal insufficiency and hypothyroidism. After my second infusion of ipi/nivo, I developed pancreatitis and hepatitis. Both of those resolved with intervention, but then the adrenal insufficiency and hypothyroidism were discovered. Since then I have now had 11 infusions of single agent nivolumab and side effects seem a little more stable. Hang in there. We all just have to pace ourselves.

Gerhard

Hi Patricia. I underwent 11 infusions of immunotherapy, specifically Opdualag in 2023-2024. I experienced fatigue and body aches throughout the entire 11 months, I also developed drug induced Type 1 diabetes and adrenal insufficiency, now requiring an insulin pump and hydrocortisone 3 times a day. Make sure your oncologist is checking your cortisol levels bc I believe they could have caught the adrenal insufficiency sooner than later in my case. By the time they found it, my level was 0. My body was not producing any cortisol. I was very sick and had lost 75 lbs. Don’t get me wrong, the immunotherapy is much better than chemo, but there are other side effects that are not discussed prior to treatment. Make sure you are getting plenty of rest and stay hydrated that also helps. Praying you feel better soon. ❤️

I had/have very similar IRAEs, which were acute reactions to my initial immunotherapy dose, but also added a myocarditis. Obviously these things are not tenable, and was admitted to ICU for two weeks after a trip to emerge. Two years later now, I continue on very low doses of cardiac medication and thyroid replacement, after the the initial treatment's incurred thyroid storm destroyed my thyroid. These medications I will likely be on for the rest of my life.

That being said, I still maintain the immunotherapy and its benefits are worth it. I am approaching dose 22 of my immunotherapy after being restarted. Fatigue is part of my everyday, but I do what I can when I can. I find it's periodic relative to the timing of my immunotherapy infusion.

Adrenal insufficiency is a medical emergency,so I hope that's being treated. Hypothyroidism, needs to be medicated, and controlled, which takes some getting used to with medication and foods timings. Controlling both of these will help with the fatigue.

I wish you the very best Patricia! Stay strong and be active when you feel up to it.