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Anyone been on Opdualag (a combination of nivolumab and relatlimab), and what was your experience?

A MyMelanomaTeam Member asked a question 💭
Callao, VA

I have stage IV melanoma in the lungs. Originally on Ipi/Nivo for two rounds and then had a bad adverse reaction. Was off treatment while that was getting under control and then on Nivolumab since September. Now it looks like it is getting active again and Opdualag is one of the possible treatments they have mentioned.

March 21
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A MyMelanomaTeam Member

I have been on Opdualag for 14 months, getting an infusion each month. My melanoma had spread to my brain, liver and spine. Today, all is well. No metabolic activity on PET results. My brain lesion was treated at U of Penn hospital using Gamma Knife. Now the lesion shows no sign of activity.

March 23
A MyMelanomaTeam Member

Thanks, Bernard! That is very encouraging, and so great to hear that you are doing well!

March 23
MyMelanomaTeam

What experiences have people had with Opdualag for stage IV melanoma?

Opdualag (nivolumab and relatlimab-rmbw) is FDA-approved for treating metastatic melanoma and tumors that can't be removed with surgery. It's a combination immunotherapy that works by blocking different immune checkpoint proteins to help your immune Show Full Answer

What experiences have people had with Opdualag for stage IV melanoma?

Opdualag (nivolumab and relatlimab-rmbw) is FDA-approved for treating metastatic melanoma and tumors that can't be removed with surgery. It's a combination immunotherapy that works by blocking different immune checkpoint proteins to help your immune system fight cancer cells.

Since you've already been on nivolumab (which is part of Opdualag) and previously had Ipi/Nivo, your oncologist is likely considering this because the relatlimab component adds another mechanism to boost your immune response.

What to know about this treatment:

* It's designed for advanced melanoma that has progressed or metastasized
* It combines two checkpoint inhibitors that work through different pathways
* Immunotherapies like this have shown promising results in extending survival for stage 4 melanoma

Important considerations given your history:

Since you had a bad adverse reaction to Ipi/Nivo, discuss with your care team how Opdualag's side effect profile might differ. While it doesn't contain ipilimumab (which may have caused your previous reaction), combination immunotherapies can still cause immune-related side effects.

Your oncologist can help weigh whether this is the right next step based on your specific situation and treatment history.

March 21

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